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A large cross-sectional study in Europe shows that nearly 10% of adult-onset diabetes in patients have diabetes-associated autoantibodies. The study is published online in Diabetes Care on December 17 DaeSean Hamilton Womens Jersey , 2012.
Many autoimmune diabetes do not need insulin therapy at the time of diagnosis. Although they tend to be younger and leaner, it does not show significantly clinical differences with negative autoantibodies in patients with type 2 diabetes generally.
"Only the screening of autoantibodies, especially glutamic acid decarboxylase autoantibodies (GADA), can clearly identify these patients." Mohammed I. Hawa and colleagues from London Queen Mary University Blizard Institute wrote.
The study included 6156 cases diagnosed with diabetes for less than 5 years (average 2.2 years) aged 30 to 70 years (mean 54.4 years) patients. The majority (84.6%) is whites, males accounted for 58.5%. These patients with latent autoimmune diabetes (LADA) are recruited from nine European countries, primary health centers, community hospitals to participate from 2004 to 2007.
In the entire patient population Josey Jewell Womens Jersey , 9.7% of patients have at least one diabetes-associated autoantibodies, including 8.8% have GADA, 2.3% have insulinoma-associated antigen -2 autoantibodies, 1.8% have zinc transporter protein autoantibodies.
In 598 cases of patients having autoantibodies, nearly 14 (24.1%) have more than one different autoantibodies, 90.5% are GADA positive. "These observations show that adult-onset autoimmune diabetes is not uncommon." The authors noted. "In clinical practice, GADA information reminds physicians: progress faster can increase the likelihood of the use of insulin therapy in patients with adult-onset diabetes."
Compared to autoantibody-negative diabetes patients Isaac Yiadom Womens Jersey , autoantibody-positive patients were significantly younger (49.6 years vs 54.9 years old, P <0.001), and significantly have lower body mass index (27.2 kgm2 vs 30.9 kgm2, P < 0.001). Their systolic blood pressure and triglyceride levels were low, high-density lipoprotein cholesterol levels were higher (P <0.001), but there is no difference between two groups of low-density lipoprotein cholesterol levels.
During the study period, 49.5% of autoantibody-positive patients were treated with insulin Courtland Sutton Womens Jersey , compared with autoantibody-negative patients, the ratio is 13.2% (P <0.001). In the 279 autoantibody-positive patients treated with insulin, the time of the 203 patients with insulin therapy is available information. In the 203 patients, 56.2% were identified with type 1 diabetes group (autoantibody positive at diagnosis, treatment with insulin).
Another 32.0% of the patients were classified as patients with LADA group (autoantibodies, but at least 6 months after diagnosis without insulin treatment). The third group accounted for the remaining 11.8%, the range between the two groups (autoantibodies Authentic Chad Kelly Jersey , between 1 to 6 months after diagnosis to start insulin therapy). Compared with LADA, typical type 1 diabetes are younger, and age of onset, body mass index, waist circumference and waist-to-hip ratio are smaller (P <0.001) .
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Engravings
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Porsche Design Tourbillon Chronograph Leather
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Replica - $150
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Replica - $135
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