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RIO DE JANEIRO http://www.winnipegjetsteamstore.com/adidas-bryan-little-jersey , Dec. 4 (Xinhua) -- Brazil's Gremio are not thinking about the prospect of playing Real Madrid in the final of this month's FIFA Club World Cup in the United Arab Emirates, according to defender Pedro Geromel.
Copa Libertadores champions Gremio will play the winner of the match between Mexico's Pachuca and Moroccan outfit Wydad Casablanca for the right to play in the final.
In the other semifinal, UEFA Champions League winners Real Madrid will meet either Asian champions Urawa Red Diamonds, Oceania's Auckland City or local club Al-Jazira.
"It doesn't help at all to be thinking about the final if we don't win the semifinal," Geromel said of the clash against Pachuca in Al-Ain on December 12.
"There are many recent examples of teams who were expected to reach the final but didn't. We are only preparing for the semifinal http://www.winnipegjetsteamstore.com/adidas-brandon-tanev-jersey ," added Geromel, who was named in the Brazilian Serie A team of the year on Monday.
South American teams have made the final in four of the last seven editions of the FIFA Club World Cup.
This year's decider will be played at the Zayed Sports City stadium in Abu Dhabi on December 16.
DNA analysis (i.e., molecular genetics) c?n b? us?d ?n evaluating lung cancer, ?nd c?n reliably separate lung tumors int? the?r morphologic categories ?f squamous, l?rg? cell http://www.winnipegjetsteamstore.com/adidas-bobby-hull-jersey , sm?ll cell, ?nd adenocarcinoma. Gene expression profiling (GEP) m?y h?ve ev?n m?r? utility ?n th? assessment ?f patients w?th non-small cell lung cancers (NSCLCs) ?nd similar histology.
Several investigators hav? attempted t? subclassify th??e tumors by correlating GEP patterns w?th clinicopathologic variables.
A series th?t included 41 lung adenocarcinomas identified thre? prognostically separate subgroups. The genes involved ?n th?s classification included thyroid transcription factor, hepsin, cathepsin L, vascular endothelial growth factor C (VEGF-C) http://www.winnipegjetsteamstore.com/adidas-blake-wheeler-jersey , ?nd th? intercellular adhesion molecule-1 (ICAM-1).
In anoth?r report ?f 139 lung adenocarcinomas defined f?ur distinct subclasses. Tumors expressing neuroendocrine-type genes h?d ? significantly les? favorable survival th?n th?se lacking such characteristics. The genes th?t defined th? neuroendocrine cluster adenocarcinomas included dopa decarboxylase, achaete-scute homolog 1, ?nd th? serine protease kallikrein 11.
Others us?d GEP t? predict outcome fr?m surgery ?n 67 patients w?th resected stage ? adenocarcinoma. A specific gr?up ?f genes distinguished high-risk fr?m l?w?r risk groups, w?th significantly differ?nt survival. Among th? 50 genes comprising th? risk index w?re erbB2, VEGF http://www.winnipegjetsteamstore.com/adidas-ben-chiarot-jersey , S100P, cytokeratin 7 ?nd 18, ?nd fas-associated death domain protein.
In an?th?r series ?f 125 patients fr?m Taiwan w?th surgically resected NSCLC, 16 genes wer? identified th?t correlated w?th increased ?r decreased survival. Further RT-PCR validation assay confirmed th? microarray findings ?nd sh?wed th?t survival w?? significantly as?oc?ated w?th f?ve ?f th? 16 genes (DUSP6, MMD http://www.winnipegjetsteamstore.com/adidas-adam-lowry-jersey , STAT1, ERBB3, ?nd LCK). The five-gene signature wa? furth?r validated ?n microarray data fr?m patients ?f Western population ?nd w?? ?n independent predictor ?f recurrence ?nd ov?rall survival f?r patients w?th surgical resection ?f NSCLC with?ut ?ny adjuvant therapy. This GEP profile i? be?ng us?d t? select h?gh risk patients f?r adjuvant chemotherapy ?n prospective clinical trials.
Lymphoma – Gene expression profiling (GEP) by me?n? ?f DNA microarrays i? ?n evolving approach t? classification, diagnosis, ?nd prognostication ?f Non-Hodgkin’s Lymphoma (NHL).
As ?n example http://www.winnipegjetsteamstore.com/ , diffuse l?rge B-cell lymphoma (DLBCL) i? ? clinically heterogeneous disease ?n wh?ch approximately 40 percent ?f patients w?th advanced stage disease respond w?ll t? combination chemotherapy ?nd ar? long-term survivors. Using GEP, DLBCL h?? be?n subclassified int? thre? distinct molecular subgroups, germinal center B-cell-like (GCB), activated B-cell-like (ABC), ?nd oth?r (type 3) http://www.winnipegjetsteamstore.com/adidas-tyler-myers-jersey , th?t app?ar t? b? derived fr?m differ?nt stages ?f B-cell differentiation, utilize diff?rent oncogenic mechanisms, ?nd d?ff?r clinically ?n th?ir ability t? b? cured by multiagent chemotherapy.
Patients wh??e tumors express genes characteristic ?f germinal center B cells (GCB) h?ve ? significantly b?tt?r outcome fr?m chemotherapy th?n th??e whos? gene expression i? mor? typical ?f activated B cells (ABC). In on? series f?r example, ? clustering algorithm applied t? 58 patients w?th DLBCL receiving cyclophosphamide, doxorubicin http://www.winnipegjetsteamstore.com/adidas-tucker-poolman-jersey , vincristine ?nd prednisone (CHOP) chemotherapy separated patients int? tw? group? w?th v?ry diff?r?nt five-year over?ll survival rates (70 v?rsu? 12 percent).
Although mo?t ?f th? e?rly studies u?ed fresh frozen tissue sections, similar results h?v? be?n reported w?th GEP performed ?n formalin-fixed, paraffin-embedded material. No formal head-to-head comparisons ?f GEP fr?m fresh ver?u? archived materials h?ve y?t be?n performed.
GEP h?s al?o be?n us?d t? develop ? m?re precise molecular diagnosis ?f primary mediastinal B-cell lymphoma, ? clinically unfavorable entity th?t c?nnot b? reliably distinguished fr?m oth?r types ?f diffuse l?rg? B-cell lymphoma. These tumors d? poorly w?th CHOP chemotherapy al?n? ?nd m?y n??d m?r? aggressive therapy th?n us?d f?r standard DLBCL.
Finally, GEP ha? th? potential t? reveal n?w therapeutic molecular targets. As ?n example http://www.winnipegjetsteamstore.com/adidas-tobias-enstrom-jersey , th? ABC subtype ?f DLBCL i? characterized by constitutive activation ?f th? nuclear factor kappaB (NF-kappaB) signaling pathway; interference w?th th?s pathway selectively kills thes? lymphoma cells. The ubiquitin-proteasomal pathway ?nd th? NF-kappaB axis ar? intimately involved ?n th? control ?f apoptosis. Inhibitors ?f th?s pathway (eg, proteasome inhibitors) c?n induce apoptosis ?n human leukemia cells th?t ectopically express th? antiapoptotic protein Bcl-2. One such agent, th? synthetic dipep. Wholesale Jerseys China Wholesale Jerseys Free Shipping Wholesale Jerseys Online Wholesale Authentic NCAA Jerseys Wholesale Nike NBA Jerseys Wholesale College Jerseys Cheap Wholesale NBA Jerseys Cheap College Jerseys Wholesale Jerseys China Cheap Soccer Jerseys |
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